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M94A3194.TXT
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1994-10-25
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Document 3194
DOCN M94A3194
TI Sequence necessary for the pathogenicity of murine AIDS (MAIDS) virus.
DT 9412
AU Ishimoto A; Kubo Y; Higo K; Kobayashi H; Hirama T; Institute for Virus
Research, Kyoto University, Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):131 (abstract no. PA0143). Unique
Identifier : AIDSLINE ICA10/94369381
AB OBJECTIVE: It was examined whether the unique sequences of defective
murine AIDS virus in its gag p15 and p12 regions are responsible for the
development of MAIDS. METHODS: Recombinant viruses by replacing various
regions of the gag gene of nonpathogenic ecotropic virus, with those of
the MAIDS virus were constructed and its pathogenicity was examined.
RESULTS: Recombinant containing both unique sequences of the MAIDS virus
were replication defective and pathogenic. However, a recombinant
containing either the gag p15 or p12 region of the MAIDS virus was
replication defective and nonpathogenic. DISCUSSION AND CONCLUSION: The
gag p15 and p12 regions of the MAIDS virus do not function as those of
replication-competent viruses, and that both of the unique sequences in
the gag p15 and p12 regions are required to develop MAIDS.
DE Animal Base Sequence Defective Viruses/GENETICS/PHYSIOLOGY Gene
Products, gag/*BIOSYNTHESIS *Genes, gag Mice Murine Acquired
Immunodeficiency Syndrome/*MICROBIOLOGY Recombination, Genetic
Retroviridae/*GENETICS/PHYSIOLOGY/*PATHOGENICITY Virus Replication
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).